antimicrobial evaluation of some novel derivatives of 3,4-dihydropyrimidine-2(1h)-one

the antimicrobial activity of thirty six novel dihydropyrimidine derivatives was evaluated against common pathogenic bacteria. significant antimicrobial activity (mic=32, 64 µg/ml) was observed. escherichia coli and pseudomonas aeruginosa as gram-negative bacteria and staphylococcus aureus as gram-positive bacteria were determined to be the most susceptible pathogens in this study. the highest inhibitory activity was observed against gram-negative microorganisms. the widest spectrum of antibacterial activity was exerted by c6 and c22 . most of the compounds had remarkable antifungal activity (mic=32 µg/ml).